Cell Culture Media, Supplements, and Reagents
Medchemexpress LLC Isonicotinic acid hydrazide-d4 | 774596-24-6 | 99.9% | 1 MG
Isoniazid-d4 is a deuterium-labeled form of Isoniazid, a proagent activated by the bacterial catalase-peroxidase enzyme KatG. It exhibits bactericidal activity against rapidly dividing mycobacteria and possesses anti-tuberculostatic properties.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes for quantitation during drug development
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC (3S,4S)-PF-06459988 | 1858291-14-1 | 99.0% | 431.88 | 100 MG
(3S, 4S)-PF-06459988 is the S enantiomer of PF-06459988 with less activity. PF-06459988 is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). It exhibits excellent selectivity against EGFR wild-type and has a minimally reactive electrophile to reduce off-target labeling. This compound is for research use only and not sold to patients.
- Inhibition of EGF-stimulated wild type EGFR autophosphorylation expressed in human A549 cells
- Inhibition of EGFR L858R/T790M double mutant autophosphorylation in human NCI-H1975 cells
- Excellent selectivity against EGFR wild-type
- Minimally reactive electrophile reduces off-target labeling
Medchemexpress LLC Kevetrin hydrochloride | 66592-89-0 | 98.0% | 179.67 | 500 MG
Kevetrin hydrochloride is a potent activator of p53. It induces apoptosis in both TP53 wild-type and mutant acute myeloid leukemia cells, exhibiting preferential cytotoxic activity against blast cells.
- Potent activator of p53.
- Induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells.
- Shows preferential cytotoxic activity against blast cells.
Medchemexpress LLC Dirithromycin | 62013-04-1 | 98.0% | 5 G
Dirithromycin is a potent and orally active semi-synthetic macrolide antibiotic, derived from Erythromycin. It is active against gram-positive bacteria, *Legionella* spp., *Helicobacter pylori*, and *Chlamydia trachomatis*. Intended for research use only.
- Exhibits antimicrobial activity similar to Erythromycin
- Shows excellent activity against several strains of *Legionella*
- Demonstrates potent activity against several strains of *Helicobacter pylori*
- Effective against experimental infections caused by *S. aureus*, *S. pyogenes*, and *S. pneumoniae* in mice
Medchemexpress LLC Vancomycin (Standard) | 1404-90-6 | 95.9% | 100 MG
Vancomycin (Standard) is an analytical standard and antibiotic used for treating bacterial infections. It is intended for research and analytical applications.
- Analytical standard for Vancomycin
- Used in qualitative, quantitative, and methodological research
- Suitable for applications such as HPLC, GC, and MS
- Treats bacterial infections
Medchemexpress LLC Tobramycin sulfate | 49842-07-1 | 98.0% | 100 MG
Tobramycin sulfate is a parenterally administered, broad-spectrum aminoglycoside antibiotic. It is effective in treating moderate to severe bacterial infections caused by sensitive organisms. It is also used in pneumonia research, particularly for infections caused by *Pseudomonas aeruginosa*.
- Broad-spectrum aminoglycoside antibiotic
- Effective against bacterial infections
- Used in pneumonia research
- Significantly decreases *P. aeruginosa* cell viability
Medchemexpress LLC Ampicillin (trihydrate) | 7177-48-2 | 99.9% | 25 G
Ampicillin trihydrate is a broad-spectrum beta-lactam antibiotic effective against various gram-positive and gram-negative bacteria. It is for research use only and not sold to patients.
- Effective against a variety of gram-positive and gram-negative bacteria.
- Inhibits E. coli growth in a dose-dependent manner.
- Alleviates symptoms of hemorrhagic enteritis in pigs.
- Produces high concentrations in bile and portal blood.
- Provides neuroprotection against ischemia-reperfusion brain injury.
Medchemexpress LLC Erythromycin (thiocyanate) | 7704-67-8 | 96.4% | 1 G
Erythromycin thiocyanate is a macrolide antibiotic produced by *Streptomyces erythreus*, known for its broad-spectrum antimicrobial activity. It functions by inhibiting bacterial 50S ribosomal subunits, thereby blocking RNA-dependent protein synthesis. This compound also exhibits antitumor and neuroprotective effects.
- Inhibits RNA-dependent protein synthesis
- Broad-spectrum antimicrobial activity
- Antitumor effects
- Neuroprotective effects
Medchemexpress LLC Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-methyl-, (16β)- | 1247-42-3 | 99.6% | 50 MG
Meprednisone is a glucocorticoid and a methylated derivative of Prednisone. It modulates glucocorticoid receptors and is orally active.
- Modulates glucocorticoid receptors
- Orally active
- Suitable for inflammation/immunology research
- Appears as a white to off-white solid
- High purity of 99.6%
Medchemexpress LLC Fenbendazole-d3 | 1228182-47-5 | 99.70% | 5 MG
Fenbendazole-d3 is a deuterium-labeled version of Fenbendazole. It acts as a HIF-1α agonist, stimulating the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent known for its broad antiparasitic effects. It functions as a microtubule destabilizing agent, leading to cell-cycle arrest and mitotic cell death, and has also demonstrated antitumor activity in mice xenografted with wild-type p53.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Reverses the inhibiting influence exerted by miR-143-5p on proliferation, colony-forming capacity, and migration in BT-549 and MCF-7 cells at 20 μM for 48 h
- Elevates the protein expression levels of HIF-1α and GLUT1 in BT-549 and MCF-7 cells at 10 μM for 48 h
Medchemexpress LLC Lobeline (hydrochloride) | 134-63-4 | 99.9% | 50 MG
Lobeline hydrochloride is a brain-penetrant nicotinic receptor agonist that increases dopamine release by inhibiting dopamine uptake into synaptic vesicles and altering presynaptic dopamine storage. It is effective in smoking cessation and is intended for research use only.
- Brain-penetrant nicotinic receptor agonist
- Increases dopamine release
- Inhibits dopamine uptake into synaptosomes and vesicles
- Effective in smoking cessation studies
- Decreases d-methamphetamine self-administration in rat models
Medchemexpress LLC Neomycin sulfate | 1405-10-3 | 99.9% | 908.88 | C23H48N6O17S | 10 MG
Neomycin sulfate is an aminoglycoside antibiotic supplied as the sulfate salt and intended for research and analytical use. It binds irreversibly to the 30S ribosomal subunit to block bacterial protein synthesis and has reported activity as a phospholipase C inhibitor and inhibitor of angiogenin nuclear translocation.
- Analytical standard for research and analytical applications.
- High purity (approx. 99.9%).
- Sulfate salt, solid form suitable for standard preparation.
- Molecular weight 908.88 g/mol.
- Packaged in 10 mg quantities for small-scale assays.
- Suitable as a reference material for microbiology and biochemical assays.
Medchemexpress LLC Penicillin V (Phenoxymethylpenicillin) | 87-08-1 | 98.9% | 5 MG
Penicillin V (Phenoxymethylpenicillin) is a potent and orally active antibiotic. It demonstrates antibacterial activity against Streptococci, Clostridium difficile, and Staphylococcus aureus, and is being researched for its potential use in conditions such as otitis, sinusitis, pharyngitis, and tonsillitis.
- Potent and orally active antibiotic
- Shows antibacterial activity against Streptococci, Clostridium difficile, and Staphylococcus aureus
- Researched for potential use in otitis, sinusitis, pharyngitis, and tonsillitis
- Acts as a β-lactam inhibitor
- Inhibits mouse OAT3 expressed in CHO cells
Medchemexpress LLC Enrofloxacin-d5 | 1173021-92-5 | 99.8% | 1 MG
Enrofloxacin-d5 is the deuterium-labeled version of Enrofloxacin. It is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis. Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuterium substitution can impact pharmacokinetic and metabolic profiles of drugs